Table 1.
All patients (n = 37) |
Non-diabetic patients (n = 20) |
Diabetes patients (n = 17) |
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Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | |
Weight (kg) | 140 (21) | 105 (25) | 93 (22) | 138 (29) | 105 (25) | 91 (22) | 143 (32) | 105 (26) | 95 (23) |
Body mass index (kg/m2) | 52 (9) | 39 (7) | 35 (7) | 51 (9) | 38 (7) | 34 (7) | 53 (9) | 40 (8) | 36 (7) |
% EWL | 46 (40–60) | 63 (51–77) | 46 (42–59) | 69 (51–77) | 49 (33–62) | 60 (48–74) | |||
Waist circumference (cm) | 141 (17) | 116 (15) | 106 (15) | 141 (16) | 114 (13) | 104 (15) | 141 (18) | 119 (18) | 109 (15) |
SBP (mmHg) | 135 (22) | 127 (20) | 124 (20) | 140 (25) | 124 (21) | 128 (23) | 129 (19) | 131 (19) | 119 (14) |
DBP (mmHg) | 74 (13) | 75 (13) | 69 (10) | 76 (15) | 73 (13) | 71 (11) | 71 (90) | 77 (12) | 68 (10) |
Total cholesterol (mmol/l) | 4.84 (1.30) | 4.94 (1.31) | 4.57 (0.80) | 5.26 (1.51) | 5.00 (91.22) | 4.76 (0.71) | 4.36 (0.80) | 4.87 (1.46) | 4.36 (0.88) |
Triglycerides (TG) (mmol/l) | 1.75 (0.84) | 1.45 (0.45) | 1.16 (0.39) | 1.55 (0.63) | 1.37 (0.47) | 1.12 (0.32) | 1.98 (1.00) | 1.54 (0.43) | 1.22 (0.46) |
Low density lipoprotein cholesterol (mmol/l) | 2.81 (1.19) | 3.04 (1.15) | 2.56 (0.77) | 3.28 (1.37) | 3.17 (1.10) | 2.75 (0.75) | 2.26 (0.61) | 2.89 (1.22) | 2.34 (0.75) |
Non-high density lipoprotein cholesterol (HDL-C, mmol/l) | 3.61 (1.21) | 3.66 (1.19) | 3.09 (0.75) | 3.99 (1.44) | 3.71 (1.11) | 3.25 (0.71) | 3.17 (0.68) | 3.59 (1.31) | 2.90 (0.77) |
Small-dense LDL apolipoprotein B (mg/dl) | 23.19 (12.01) | 13.86 (7.51) | 11.57 (5.39) | 24.23 (14.75) | 13.46 (5.57) | 11.10 (5.07) | 22.04 (8.24) | 14.34 (9.54) | 12.10 (5.84) |
ApoB (g/l) | 0.96 (0.25) | 1.01 (0.31) | 0.88 (0.20) | 1.01 (0.30) | 1.01 (0.30) | 0.91 (0.20) | 0.90 (0.16) | 1.02 (0.34) | 0.84 (0.20) |
HDL-C (mmol/l) | 1.22 (0.29) | 1.28 (0.34) | 1.4 (0.34) | 1.26 (0.34) | 1.28 (0.37) | 1.51 (0.35) | 1.18 (0.22) | 1.27 (0.31) | 1.46 (0.34) |
ApoA (g/l) | 1.33 (0.23) | 1.31 (0.24) | 1.36 (0.22) | 1.28 (0.27) | 1.27 (0.25) | 1.35 (0.24) | 1.39 (0.17) | 1.35 (0.23) | 1.38 (0.21) |
Adiponectin (mg/l) | 1.59 (0.70) | 2.15 (0.88) | 2.74 (1.16) | 1.64 (0.75) | 2.22 (0.93) | 2.90 (1.22) | 1.54 (0.66) | 2.07 (0.83) | 2.56 (1.09) |
Leptin (ng/l) | 85.87 (49.50) | 32.63 (26.86) | 23.72 (24.06) | 91.86 (51.04) | 33.37 (27.45) | 22.64 (15.28) | 78.82 (48.19) | 31.71 (26.98) | 25.00 (31.98) |
HOMA-IR | 8.12 (6.69) | 3.80 (4.27) | 2.68 (2.79) | 6.02 (3.48) | 3.57 (5.34) | 1.95 (1.63) | 10.60 (8.63) | 4.10 (2.50) | 3.53 (3.61) |
CRP (mg/l) | 10.25 (10.66) | 5.42 (7.69) | 2.20 (2.51) | 9.23 (9.52) | 4.83 (5.83) | 2.00 (2.08) | 11.46 (12.05) | 6.16 (9.70) | 2.43 (2.99) |
Tumor necrosis factor-alpha (pg/ml) | 33.50 (39.50) | 30.50 (51.09) | 11.33 (29.90) | 33.04 (38.36) | 31.49 (40.50) | 15.89 (39.17) | 34.04 (41.94) | 29.26 (63.32) | 5.96 (11.53) |
Monocyte chemoattractant protein 1 (pg/ml) | 288 (147) | 222 (129) | 154 (84) | 273 (148) | 207 (116) | 162 (80) | 307 (149) | 240 (146) | 145 (91) |
Intercellular adhesion molecule 1 (ng/ml) | 226 (104) | 184 (75) | 134 (38) | 224 (73) | 176 (54) | 135 (39) | 228 (134) | 193 (96) | 134 (38) |
E-selectin (ng/ml) | 12.05 (5.80) | 9.50 (3.87) | 3.10 (3.67) | 11.89 (5.32) | 7.33 (3.11) | 7.52 (3.41) | 12.30 (6.48) | 7.71 (4.75) | 6.61 (4.00) |
P-selectin (ng/ml) | 36.22 (13.95) | 30.37 (10.75) | 23.16 (7.52) | 37.13 (14.47) | 29.30 (9.90) | 22.87 (6.03) | 35.15 (13.68) | 31.70 (11.91) | 23.48 (9.13) |
Resistin (ng/ml) | 14.78 (6.20) | 14.60 (6.54) | 11.30 (5.32) | 14.39 (3.78) | 14.66 (5.33) | 12.02 (4.91) | 15.23 (8.32) | 14.53 (7.98) | 10.44 (5.80) |
Values in mean ± SD. No patients were lost to follow-up.