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. 2017 Nov 15;196(10):1275–1286. doi: 10.1164/rccm.201701-0170OC

Figure 1.

Figure 1.

Human mesenchymal stromal cell (MSC) modulation of human monocyte–derived macrophage (MDM) phenotype and function. (A) MSCs in noncontact coculture reduced the production of tumor necrosis factor (TNF)-α by MDMs after 24 hours of LPS treatment. One-way analysis of variance (ANOVA) with Bonferroni’s post hoc test was used (n = 5 per group). (B) IL-8 production by MDMs was reduced by MSC coculture after LPS treatment. One-way ANOVA with Bonferroni’s post hoc test was used (n = 4 per group). (C) MSC coculture increased the percentage of MDMs expressing CD206 on their surface in the (Ci) absence or (Cii) presence of LPS. Unpaired t test (n = 3 per group) and one-way ANOVA with Bonferroni’s post hoc test (n = 4 per group), respectively, were used. (D) MSCs increased the proportion of MDMs that had phagocytosed Escherichia coli pHrodo (Thermo Fisher Scientific, Carlsbad, CA) dye-stained fluorescent bioparticles after LPS. One-way ANOVA with Bonferroni’s post hoc test was used (n = 5 per group). Data are presented as mean ± SD. *P < 0.05; **P < 0.01.