Table 1.
Effect of Human Mesenchymal Stromal Cells on Human Monocyte–derived Macrophage Cytokine and Chemokine Secretion after LPS Stimulation
| Analyte | Concentration (pg/ml) |
P Value | |
|---|---|---|---|
| LPS | LPS + MSC | ||
| M1 associated | |||
| IFN-γ | ND | ND | — |
| IL-1β | ND | ND | — |
| IL-8 | 9,155 ± 1,790 | 6,410 ± 1,676 | <0.05 |
| IL-12p70 | ND | ND | — |
| IL-17 | ND | ND | — |
| IL-23 | 37,856 ± 27,577 | 23,858 ± 17,544 | 0.361 |
| TNF-α | 2,465 ± 1,103 | 1,038 ± 207 | <0.05 |
| CCL5 | 9,571 ± 8,032 | 5,885 ± 4,392 | 0.404 |
| M2 associated | |||
| IL-1ra | 120,143 ± 34,335 | 110,304 ± 27,258 | 0.627 |
| IL-10 | ND | ND | — |
| CCL17 | 678 ± 607 | 341 ± 228 | 0.589 |
| CCL18 | 904 ± 604 | 292 ± 190 | 0.056 |
| CCL22 | 106,211 ± 67,673 | 22,486 ± 13,267 | <0.05 |
Definition of abbreviations: CCL = chemokine (C-C motif) ligand; MSC = human mesenchymal stromal cell; ND = no data; TNF-α = tumor necrosis factor-α.
Data are presented as mean ± SD.