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Possible mechanisms of limiting fusion pore expansion. (A) Adhesion between the dense core and the inner surface of the vesicle membrane would maintain the omega shape and oppose expansion of the fusion pore. (B) Dynamin forming a ring or collar around the fusion pore would resist expansion. (C) Synaptotagmin anchored in the vesicle membrane by its membrane-spanning α-helix and attached to the plasma membrane by its C2B domain would resist expansion.
