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. 2016 Dec 19;36(4):503–519. doi: 10.15252/embj.201695135

Figure 7. Model showing cell cycle‐regulated control of resolution of telomere cohesion by K63‐ubiquitination of tankyrase 1.

Figure 7

In late S/G2 following DNA replication (and in conjunction with the ATM‐mediated DNA damage response at functional telomeres), RNF8 puts K63‐Ub chains on tankyrase 1, promoting its association with telomeres and sister telomere resolution. Following nuclear envelope breakdown, ABRO1 (and BRCC36) gains access to K63‐Ub TNKS1 and removes the chains. ABRO1 remains in the nucleus through G1 keeping the K63‐Ub chains off tankyrase 1 and preventing premature resolution of telomere cohesion in S phase. ABRO1 is exported from the nucleus in S phase to permit K63‐ubiquitination of tankyrase 1. C, cytoplasm; N, nucleus.