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. 2017 Sep 20;7(17):4071–4086. doi: 10.7150/thno.20168

Figure 4.

Figure 4

Pharmaceutical profile and biodistribution of PEGylated Apt-DOX. (A) Pharmacokinetic profiles of DOX after a single i.v. injection of free DOX, PEGylated Apt-DOX and control PEGylated Apt-DOX conjugate into SD rats at an equivalent dosage of 5 mg/kg DOX followed by quantification of DOX in blood plasma. (B) Biodistribution profiles of DOX accumulation in tumour and organs 24 h after i.v. injection of agents at an equivalent dosage of 5 mg/mL DOX. (C-D) Biodistribution of DOX in the tumour (C) and heart (D), 24 h after i.v. injection. Data shown are means ± SEM. (n=3, unless indicated otherwise). *P < 0.05, **P < 0.01 compared with free DOX administration groups (two-tailed Student's t-test).