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. 2017 Sep 21;7(17):4099–4117. doi: 10.7150/thno.20730

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NB cell populations and effect of INN on the bioengineered tumors (TE-NB) (a) Effect of INN on both CD31+ and MYC+ compartments and on vasculogenic mimicry in the TE-NB model. INN targets NB cells (MYCN+); TECs (MYCN⁺/CD31⁺) are drug-resistant and can proliferate; there was no effect on the number of HUVECs in the vessels. INN can also induce destabilization of CD31+ vessels by downregulation of CD31 without altering vessel-like structures (PAS+/CD31-). (b) Effect of INN on SOX2+ cells. SOX2-high subpopulation enrichment after INN treatment shows the shift from low to high SOX2 levels. (c) Hypothetical mechanism for tumor relapse after chemotherapy based on data obtained from the TE-NB model treated with INN.