Figure 4.

Enhanced cancer theranostics effect of NaDyF₄:10%Nd-GA-Fe in vitro and in vivo. T₂-weighted MRI images in pre- and post-incubated cells A) and tumor-bearing mice within 120 min post-injection B). C) T₂-weighted MRI signal in tumor region after intratumorous injection of NaDyF₄:10%Nd-GA-Fe. NIR II DCL images in pre- and post-incubated cells D) and tumor-bearing mice E). F) Photothermal therapy efficiency in vitro. G) Photothermal images in pre- and post-injection tumor-bearing mice. H) Tumor growth rates of test group (Material + Laser), control groups (Laser only, Materials only) and blank group (Blank). I) Tissue distribution of NaDyF₄:10%Nd-GA-Fe within 1 and 4 hour post-injection intravenously. NaDyF₄:10%Nd-CA-Fe was used for comparison (control in 4A and 4D). Statistical significance was determined from one-way t tests. Note.*p < 0.05, **p < 0.01, ***p < 0.001