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Initiation of additional radiotherapy (RT) based on molecular imaging of M2 macrophages leads to significantly improved tumor suppression. (A) Schematic illustration showing the design of CTX and RT combination therapy (Control, n = 5; CTX-S, n = 6; CTX-S + RT-1, n = 6; CTX-S + RT-2, n = 6). (B) 4T1 tumor growth curves after combination therapy. (C-D) Tumor weights (C) and photographs (D) from 4T1 tumor-bearing mice on day 28 after the indicated treatments. **, P <0.01; ***, P <0.001.
