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Knockout of Sirt3 abolishes apelin induced suppression of ROS formation in EPC. (A) Representative images of overexpression of apelin on ROS formation in EPC under High Glucose (HG) conditions in vitro. (B) Overexpression of Ad-apelin in EPC attenuated HG-induced ROS formation (n=5, †P<0.001). The inhibitory effect of apelin on HG-induced ROS formation was abolished in Sirt3 KO-EPC. (C) Treatment of Sirt3 KO-EPC with apo (200 and 400 μM) enhanced LC-3 II expression.
