Table 4.
Mean log gingival crevicular fluid IL-1β levels (standard errors) and relative (fold) changes contrasting 2.2 vs. 1.1, according to rs6940 and rs1057028 genotypes (adjusted for plaque levels).
| SNP | n | Mean log IL-1β (SE) |
|---|---|---|
| rs6940* | ||
| 1.1 | 3359 | 2.05 (0.01) |
| 1.2 | 976 | 2.04 (0.01) |
| 2.2 | 73 | 2.08 (0.04) |
| Fold change | 3.05 | |
| rs1057028* | ||
| 1.1 | 3006 | 2.05 (0.01) |
| 1.2 | 1255 | 2.04 (0.01) |
| 2.2 | 147 | 2.10 (0.03)† |
| Fold change | 5.13 | |
*
haplotype blocks for both SNPs include additional SNPs shown on table 1
†
chi-square p≤0.05 using 1.1 as the referent category; fold change comparing 2.2 vs. 1.1