Supplementary Table 1.
The distribution of 11 tumor stage systems in training and validation datasets
| Tumor stage system | Cohort 1 (n = 4166), n (%) | Cohort 2 (n = 1978), n (%) | Cohort 3 (n = 808), n (%) | Cohort 4 (n = 244), n (%) |
|---|---|---|---|---|
| AJCC-TNM | ||||
| I | 2273 (55) | 1073 (54) | 593 (73) | 66 (27) |
| II | 1175 (28) | 546 (28) | 202 (25) | 140 (57) |
| III | 654 (16) | 315 (16) | 10 (1) | 17 (7) |
| IV | 64 (2) | 44 (2) | 3 (0) | 21 (9) |
| UNOS-TNM | ||||
| I | 249 (6) | 172 (9) | 83 (10) | 13 (5) |
| II | 1879 (45) | 984 (50) | 622 (77) | 110 (45) |
| III | 1456 (35) | 630 (32) | 100 (12) | 82 (34) |
| IV | 582 (14) | 192 (10) | 3 (0) | 39 (16) |
| Japan TNM | ||||
| I | 249 (6) | 171 (9) | 83 (10) | 13 (5) |
| II | 2079 (50) | 1272 (64) | 663 (82) | 170 (70) |
| III | 1648 (40) | 408 (21) | 59 (7) | 55 (23) |
| IV | 190 (5) | 127 (6) | 3 (0) | 6 (2) |
| Okuda | ||||
| I | 3576 (86) | 1724 (87) | 766 (95) | 193 (79) |
| II | 561 (13) | 254 (13) | 41 (5) | 51 (21) |
| III | 29 (1) | 0 | 1 (0) | 0 |
| CS stage | ||||
| I | 1928 (46) | 1159 (59) | 698 (86) | 134 (55) |
| II | 1661 (40) | 569 (29) | 98 (12) | 107 (44) |
| III | 577 (14) | 250 (13) | 12 (1) | 3 (1) |
| BCLC stage | ||||
| 0–A | 1827 (44) | 1136 (57) | 697 (86) | 186 (76) |
| B | 1839 (44) | 720 (36) | 111 (14) | 30 (12) |
| C–D | 500 (12) | 122 (6) | 0 (0) | 28 (11) |
| JIS score | ||||
| 0 | 242 (6) | 168 (8) | 82 (10) | 13 (5) |
| 1 | 2043 (49) | 1242 (63) | 656 (81) | 169 (69) |
| 2 | 1639 (39) | 423 (21) | 67 (8) | 54 (22) |
| 3 | 231 (6) | 141 (7) | 3 (0) | 8 (3) |
| 4 | 11 (0) | 4 (0) | 0 | 0 |
| CLIP | ||||
| 0 | 1924 (46) | 1104 (56) | 506 (63) | 117 (48) |
| 1–3 | 1902 (46) | 866 (44) | 302 (37) | 114 (47) |
| 4–6 | 340 (8) | 8 (0) | 0 | 13 (5) |
| CUPI | ||||
| <1 | 4135 (99) | 1961 (99) | 808 (100) | 238 (98) |
| 2–7 | 29 (1) | 17 (1) | 0 | 8 (2) |
| >8 | 2 (0) | 0 | 0 | 0 |
| Eastern stage | ||||
| 0–1 | 1208 (29) | 956 (48) | 357 (44) | 53 (22) |
| 2–3 | 2289 (55) | 852 (43) | 411 (51) | 190 (78) |
| 4–8 | 669 (16) | 170 (9) | 40 (5) | 1 (0) |
| HKLC | ||||
| I | 1741 (42) | 910 (46) | 6 (1) | 50 (20) |
| II | 2246 (54) | 958 (48) | 579 (72) | 112 (46) |
| III | 179 (4) | 110 (6) | 223 (28) | 82 (34) |
BCLC: Barcelona Clinic Liver Cancer Staging; AJCC: American Joint Committee on Cancer; TNM: Tumor node metastasis; CLIP: Cancer of the Liver Italian Program score; CS: Chinese Staging; UNOS: United Network for Organ Sharing; JIS: Japan Integrated Staging score; CUPI: Chinese University Prognostic Index staging; HKLC: Hong Kong Liver Cancer Staging System.