Table 2.
Multivariate analysis of clinical indicators for prognostic prediction in training cohort (n = 4166)
| Variables | Up:low* | Overall survival | ||
|---|---|---|---|---|
| Coefficient | P | HR (95% CI) | ||
| Age | 60:44 | 0.0082 | <0.001 | 1.01 (1.00–1.01) |
| HBsAg | Positive: negative | 0.1703 | 0.020 | 1.19 (1.02–1.37) |
| HBeAg | Positive: negative | 0.2954 | <0.001 | 1.34 (1.22–1.48) |
| AFP | 1210:8 | 0.0400 | <0.001 | 1.04 (1.02–1.06) |
| TB | 19:11 | 0.0023 | 0.020 | 1.00 (1.00–1.00) |
| PTT | 13:11 | 0.0876 | <0.001 | 1.09 (1.05–1.13) |
| AKP | 109:66 | 0.1669 | 0.007 | 1.18 (1.05–1.33) |
| GGT | 115:38 | 0.1775 | <0.001 | 1.19 (1.12–1.27) |
| Size | 7.5:3.0 | 0.0818 | <0.001 | 1.09 (1.07–1.10) |
| Cirrhosis | Yes:no | 0.1629 | 0.007 | 1.18 (1.05–1.32) |
| Vascular invasion | Micro:none | 0.4057 | <0.001 | 1.50 (1.35–1.67) |
| Macro:none | 0.8460 | <0.001 | 2.33 (2.01–2.70) | |
| Differentiation | III–IV:I–II | 0.2981 | <0.001 | 1.35 (1.22–1.48) |
| Encapsulation | Yes:no | −0.1743 | <0.001 | 0.84 (0.76–0.93) |
| Number | Double:single | 0.3740 | <0.001 | 1.45 (1.27–1.66) |
| Multiple:single | 0.3989 | <0.001 | 1.49 (1.30–1.70) | |
*Upper quartile vs. lower quartile. HR: Hazard ratio; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; PTT: Partial thromboplastin time; TB: Total bilirubin; AKP: Alkaline phosphatase; GGT: γ-glutamyltransferase; AFP: α-fetoprotein; CI: Confidence interval.