Supplementary Table 3.

Performance of different staging systems in training and validation datasets*

Items	Cohort 1 (n = 4166)			Cohort 2 (n = 1978)			Cohort 3 (n = 808)			Cohort 4 (n = 244)
	ΔLHR	P	ΔAIC	ΔLHR	P	ΔAIC	ΔLHR	P	ΔAIC	ΔLHR	P	ΔAIC
Removing Shanghai Score	−272.359	<0.001	270.359	−78.960	<0.001	76.960	−32.400	<0.001	30.400	−9.937	0.001	7.937
Removing BCLC	−0.981	0.320	−1.019	−28.185	<0.001	26.185	−0.151	0.698	−1.849	−1.454	0.224	−0.546
Removing TNM	−1.277	0.257	−0.723	−0.855	0.356	−1.145	−0.127	0.724	−1.873	−0.172	0.679	−1.828
Removing CLIP	−0.371	0.542	−1.629	−0.125	0.723	−1.875	−0.363	0.548	−1.637	−1.116	0.291	−0.884
Removing OKUDA	−0.966	0.327	−1.034	−2.071	0.145	0.071	−0.833	0.374	−1.167	−0.329	0.566	−1.671
Removing C stage	0	0.989	−2.000	−20.184	<0.001	18.184	−0.202	0.657	−1.798	−0.001	0.978	−1.999
Removing UNOS	−0.052	0.820	−1.948	−22.213	<0.001	20.213	−0.169	0.685	−1.831	−1.790	0.177	−0.210
Removing JIS score	−1.452	0.223	−0.548	−5.134	0.027	3.134	−0.002	0.961	−1.998	−0.233	0.639	−1.767
Removing Japan TNM	−0.906	0.337	−1.094	−4.531	0.036	2.531	−0.005	0.941	−1.995	−1.360	0.266	−0.640
Removing CUPI	−0.103	0.749	−1.897	−0.117	0.755	−1.883	−0.008	0.929	−1.992	−0.002	0.966	−1.998
Removing Eastern System	−0.110	0.741	−1.890	−2.883	0.091	0.883	−2.869	0.092	0.869	−4.441	0.036	2.441
Removing HKLC	−0.061	0.805	−1.939	−0.127	0.721	−1.873	−1.797	0.182	−0.203	−1.617	0.201	−0.383

*In multivariate analysis, the independent contribution of each staging system in the full model was assessed by removing the concerned system. ΔLHR was calculated by frst fitting full model and then removing one concerned system, at last ΔLHR = LHR_{removing model} - LHR_{full model}; the same to ΔAIC. Larger drop of ΔLHR and increase of AIC indicate more information of the removed system. LHR: Likelihood ratio; AIC: Akaike information criterion; BCLC: Barcelona Clinic Liver Cancer staging; AJCC: American Joint Committee on Cancer; TNM: Tumor node metastasis; CLIP: Cancer of the Liver Italian Program score; CS: Chinese Staging; UNOS: United Network for Organ Sharing; JIS: Japan Integrated Staging score; CUPI: Chinese University Prognostic Index Staging; HKLC: Hong Kong Liver Cancer Staging System.