Comparison of the baseline characteristics of age, serum HBsAg, HBeAg quantitation in the minimal, mild, moderate grades of liver inflammation in treatment-naïve HBeAg-positive chronic HBV-infected patients. (a) The comparison results of the baseline age of the minimal, mild, moderate grade in treatment-naïve HBeAg-positive chronic HBV-infected patients. As age increases, liver inflammation grades increase. Minimal versus mild (z = −51.870, P < 0.001); minimal versus moderate (z = −103.178, P < 0.001); mild versus moderate (z = −51.308, P = 0.033). (b) The comparison results of the baseline HBsAg of the minimal, mild, moderate grade in treatment-naïve HBeAg-positive chronic HBV-infected patients. As the quantitation of HBsAg decrease, inflammation grades increase. Minimal versus mild (z = 100.788, P < 0.001); minimal versus moderate (z = 199.578, P < 0.001); mild versus moderate (z = 98.790, P < 0.001). (c) The comparison results of the baseline HBeAg the minimal, mild, moderate grade in HBeAg-positive CHB. As the quantitation of HBeAg decrease, inflammation grades increase. Minimal versus mild (z = 94.092, P < 0.001); minimal versus moderate (z = 207.829, P < 0.001); mild versus moderate (z = 113.804, P < 0.001). HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; S/CO: Sample/cutoff; CHB: Chronic hepatitis B.