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. 2017 Sep 15;31(18):1870–1879. doi: 10.1101/gad.301093.117

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© 2017 Miki et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Assignment of XRN2 independence is robust to different XRN2 depletion strategies and not explained by gene expression levels or dynamics. (A–C) Scatter plots comparing log₂ fold change of read density in downstream regions in three experiments inactivating XRN2 as indicated. In all experiments involving the xrn-2(xe31ts) allele, xrn-2 inactivation was achieved by a 10-h shift to restrictive temperature. XDT (XRN2-dependent for termination) genes as defined in the xrn-2(RNAi) experiment are colored red. (D,E) Scatter plots showing the log₂ fold change of read density in downstream regions upon xrn-2(RNAi) versus the log₂ mean mRNA expression levels in xrn-2(RNAi) conditions (D) or the log₂ fold change of the corresponding mRNA expression levels upon xrn-2(RNAi) (E). XDT genes are shown in red.