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Passive immunization with anti-OmpA MAb 7D4 did not provide protection against AB307-0294 (wt; K1 capsule positive) in a mouse sepsis infection model. BALB/c mice (n = 10 per group) were infected with 2.1 × 109 CFU AB307-0294 via subcutaneous injection and immediately treated intraperitoneally with 50 mg/kg 7D4 or 200 μl PBS. Survival data were analyzed using a log rank (Mantel-Cox) test.
