Table A3.
Net reclassification improvement examine the incremental value of ECG markers over clinical (model I), ECG marker over clinical +1 echo (model II), and ECG marker over clinical +2 echo markers (model III)
| Model I (clinical + ≥1 abnormal ECG marker) | Increased risk | Decreased risk | Net correctly reclassified % | |||||
|---|---|---|---|---|---|---|---|---|
| Composite endpoints (n = 49) | Quartile 1 (<6.24%) | Quartile 2 (6.24–9.57%) | Quartile 3 (9.57–15.6%) | Quartile 4 (≥15.69%) | n | n | % | |
| (Clinical) | ||||||||
| Quartile 1 (<6.24%) | 5 | 0 | 0 | 0 | 6 | 1 | 10.2 | |
| Quartile 2 (6.24–9.57%) | 1 | 6 | 0 | 0 | ||||
| Quartile 3 (9.57–15.6%) | 0 | 0 | 10 | 6 | ||||
| Quartile 4 (≥15.69%) | 0 | 0 | 0 | 21 | ||||
| No event (n = 358) | ||||||||
| Quartile 1 (<6.24%) | 81 | 13 | 0 | 0 | 38 | 44 | 0.3 | |
| Quartile 2 (6.24–9.57%) | 16 | 66 | 14 | 0 | ||||
| Quartile 3 (9.57–15.6%) | 0 | 18 | 61 | 11 | ||||
| Quartile 4 (≥15.69%) | 0 | 0 | 10 | 67 | ||||
| Net reclassification improvement = 0.11 | 0.105 | |||||||
| P = 0.065 | ||||||||
| Model II (clinical +1 echo + ≥1 abnormal ECG) | Increased risk | Decreased risk | Net correctly reclassified % | |||||
|---|---|---|---|---|---|---|---|---|
| Composite endpoints (n = 49) | Quartile 1 (<6.32%) | Quartile 2 (6.32–9.42%) | Quartile 3 (9.42–15.87%) | Quartile 4 (≥15.99%) | n | n | % | |
| (Clinical + 1echo) | ||||||||
| Quartile 1 (<6.32%) | 4 | 0 | 0 | 0 | 4 | 0 | 8.2 | |
| Quartile 2 (6.32–9.42%) | 3 | 5 | 0 | 0 | ||||
| Quartile 3 (9.42–15.87%) | 0 | 0 | 11 | 4 | ||||
| Quartile 4 (≥15.99%) | 0 | 0 | 0 | 22 | ||||
| Reclassified | ||||||||
| Increased risk | Decreased risk | Net correctly reclassified % | ||||||
| No event (n = 358) | Quartile 1 (<6.32%) | Quartile 2 (6.32–9.42%) | Quartile 3 (9.42–15.87%) | Quartile 4 (≥15.99%) | n | n | % | |
| Quartile 1 (<6.32%) | 83 | 11 | 0 | 0 | 37 | 38 | 0.3 | |
| Quartile 2 (6.32–9.42%) | 18 | 64 | 14 | 0 | ||||
| Quartile 3 (9.42–15.87%) | 0 | 12 | 68 | 12 | ||||
| Quartile 4 (≥15.99%) | 0 | 0 | 8 | 62 | ||||
| Net reclassification improvement = 0.085 | 0.085 | |||||||
| P = 0.074 | ||||||||
| Model II (clinical +2 Echo + ≥1 abnormal ECG) | Increased risk | Decreased risk | Net correctly reclassified % | |||||
|---|---|---|---|---|---|---|---|---|
| Composite endpoints (n = 49) | Quartile 1 (<5.69%) | Quartile 2 (5.69–9.42%) | Quartile 3 (9.42–15.76%) | Quartile 4 (≥15.76%) | n | n | % | |
| (Clinical+ 2 Echo) | ||||||||
| Quartile 1 (<5.69%) | 5 | 0 | 0 | 0 | 1 | 4 | −6.1 | |
| Quartile 2 (5.69–9.42%) | 1 | 5 | 0 | 0 | ||||
| Quartile 3 (9.42–15.76%) | 0 | 1 | 7 | 1 | ||||
| Quartile 4 (≥15.76%) | 0 | 0 | 2 | 27 | ||||
| Reclassified | ||||||||
| Increased Risk | Decreased Risk | Net correctly reclassified % | ||||||
| No event (n = 358) | Quartile 1 (<5.69%) | Quartile 2 (5.69–9.42%) | Quartile 3 (9.42–15.76%) | Quartile 4 (≥15.76%) | n | n | % | |
| Quartile 1 (<5.69%) | 84 | 11 | 0 | 0 | 23 | 40 | 4.7 | |
| Quartile 2 (5.69–9.42%) | 15 | 75 | 8 | 0 | ||||
| Quartile 3 (9.42–15.76%) | 0 | 17 | 71 | 4 | ||||
| Quartile 4 (≥15.76%) | 0 | 0 | 8 | 63 | ||||
| Net reclassification improvement = −0.014 | −0.014 | |||||||
ECG, electrocardiogram.
Clinical = age, gender, Charlson score.