Table 3.
Diagnostic characteristics—comparison of ECG markers using conventional cut‐offs, gender specific upper quartile cut‐offs for detection of stage B heart failure
| Left ventricular hypertrophy | Impaired global longitudinal strain | Diastolic dysfunction (≥ stage I) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| #LVH/total# at risk (PPV) | #LVH/total# LVH (sensitivity) | P | #AbnGLS/total# at risk (PPV) | #AbnGLS/total# AbnGLS (sensitivity) | P | #DD/total# at risk (PPV) | #DD/total# DD (sensitivity) | P | |
| Single ECG marker and cut‐off | |||||||||
| Cornell product 75th (m > 1442, f > 1518) | 26/111 (23%) | 26/58 (45%) | <0.001 | 42/111 (38%) | 42/142 (30%) | 0.113 | 85/111 (77%) | 85/289 (29%) | 0.002 |
| Abnormal PTFV1 (≤−4000 μV·ms) | 17/156 (11%) | 17/58 (29%) | 0.338 | 48/156 (31%) | 48/142 (34%) | 0.740 | 105/156 (67%) | 105/289 (36%) | 0.390 |
| Abnormal minSTmV5V6(≤−20 μV) | 19/119 (16%) | 19/58 (32%) | 0.257 | 45/119 (38%) | 45/142 (32%) | 0.098 | 80/119 (67%) | 80/289 (28%) | 0.493 |
| Abnormal heart rate(≥80 bpm) | 5/57 (9%) | 5/58 (9%) | 0.312 | 26/57 (46%) | 26/142 (18%) | 0.016 | 45/57 (79%) | 45/289 (16%) | 0.016 |
| Combined ECG markers | |||||||||
| Presence of ≥1 abnormal ECG | 44/296 (15%) | 44/58 (76%) | 0.096 | 96/296 (32%) | 96/142 (68%) | 0.672 | 205/296 (69%) | 205/289 (71%) | 0.004 |
| Presence of ≥2 abnormal ECG | 17/115 (15%) | 17/58 (29%) | 0.503 | 48/115 (42%) | 48/142 (34%) | 0.008 | 83/115 (72%) | 83/289 (29%) | 0.050 |
| Presence of ≥3 abnormal ECG | 5/29 (17%) | 5/58 (9%) | 0.480 | 15/29 (52%) | 15/142 (11%) | 0.017 | 24/29 (83%) | 24/289 (8%) | 0.035 |
DD, diastolic dysfunction; ECG, electrocardiogram; GLS, global longitudinal strain; LVH, left ventricular hypertrophy; PPV, positive predictive value.
# = number of participants.