Table 5.
Outcome | Predictor variable | HR | 95% CI, HR | P value |
---|---|---|---|---|
Single heart rate determination | ||||
All‐cause death | Carvedilol‐equiv dose (mg) | 0.983 | 0.970, 0.997 | 0.017 |
NE level (ng/mL) | 1.0007 | 1.0002, 1.0011 | 0.002 | |
H/M | 0.078 | 0.0201, 0.288 | 0.0001 | |
Cardiac death | Carvedilol‐equiv dose (mg) | 0.984 | 0.968, 1.001 | 0.059 |
NE level (ng/mL) | 1.0007 | 1.0003, 1.0012 | 0.002 | |
H/M | 0.044 | 0.008, 0.228 | 0.0002 | |
Arrhythmic event | H/M | 0.244 | 0.076, 0.780 | 0.018 |
Mean heart rate, multiple determinations | ||||
All‐cause death | Carvedilol‐equiv dose (mg) | 0.984 | 0.970, 0.998 | 0.024 |
NE level (ng/mL) | 1.0006 | 1.0002, 1.0010 | 0.003 | |
H/M | 0.082 | 0.022, 0.308 | 0.0002 | |
Cardiac death | Carvedilol‐equiv dose (mg) | 0.986 | 0.969, 1.002 | 0.089 |
NE level (ng/mL) | 1.0007 | 1.0002, 1.0011 | 0.004 | |
H/M | 0.051 | 0.008, 0.228 | 0.0005 | |
Arrhythmic event | H/M | 0.330 | 0.097, 1.123 | 0.077 |
CI, confidence interval; H/M, heart to mediastinum ratio; HR, hazard ratio; NE, norepinephrine.
Variables tested: carvedilol‐equivalent dose, norepinephrine level, baseline heart rate, and H/M ratio.