TABLE 1.
Literature review of major BRAFV600E-positive papillary and/or poorly differentiated thyroid carcinoma genetically engineered mouse models
| Reference | Line | Strain | Age, weeks | Metastasis | ||
|---|---|---|---|---|---|---|
| Local | Lymph node | Distant | ||||
| Knauf et al14 2005 | Tg-BRAF2 | FVB/N | 22 | Y | Y | N |
| Knauf et al14 2005 | Tg-BRAF3 | FVB/N | 22 | N | Y | N |
| Franco et al15 2011 | LSL-BrafV600E/TPO-Cre | C57BL/6 | 5 | Y | N | N |
| Chakravarty et al17 2011 | Tg-rtTA/tetO-BRAFV600E | FVB/N | 12DI | Y | N | N |
| Charles et al10 2011 | Thyro:CreER/BRAFCA/+ | C57BL/6 | 48TI | N | N | N |
| McFadden et al16 2014 | Thyro:CreER/BRAFCA/+/Trp53F/F | C57BL/6 | 24TI | Y | N | Y |
| Charles et al40 2014 | Thyro:CreER/BRAFCA/+/Pik3caLat/+ | FVB/N | 48TI | Y | N | N |
| Jolly et al18 2016 | BrafV600E/Pten−/−/TPO-Cre | C57BL/6 | <1 | Y | N | N |
| Hinson et ala 2016 | LSL-BrafV600E/TPO-Cre | C57BL/6 | 5 | N | N | N |
| Hinson et ala 2016 | LSL-BrafV600E/Pten+/−/TPO-Cre | C57BL/6 | 12 | Y | N | N |
Abbreviations: DI, doxycycline inducible; TI, tamoxifen inducible.
a
Presented herein.