Table 4.

Diagnostic Properties of Specific Thresholds of Selected Salivary Biomarkers and Plaque Biofilm Pathogens

Biomarker	Threshold	Above Threshold	Periodontitis		Sensitivity	Specificity	OR	95% CI
			No (n)	Yes (n)
MMP-8 (ng/ml)	87.0	−	28	12	0.69	0.70	5.3	2.0 to 13.7
		+	12	27
MMP-9 (ng/ml)	240.0	−	28	12	0.69	0.70	5.3	2.0 to 13.7
		+	12	27
Calprotectin (ng/ml)	3.6	−	25	15	0.62	0.63	2.7	1.1 to 6.6
		+	15	24
IL-6 (pg/ml)	22.4	−	24	16	0.59	0.60	2.2	0.9 to 5.3
		+	16	23
IL-1β (pg/ml)	235.8	−	22	18	0.54	0.55	1.4	0.6 to 3.5
		+	18	21
IL-10 (pg/ml)	520.9	−	22	18	0.54	0.55	1.4	0.6 to 3.5
		+	18	21
OPG (pg/ml)	2.0	−	17	22	0.44	0.43	0.6	0.2 to 1.4
		+	23	17
ICTP (ng/ml)	0.7	−	16	23	0.41	0.40	0.5	0.2 to 1.1
		+	24	16
T. denticola (%)	0.2	−	33	7	0.82	0.83	21.6	6.8 to 68.4
		+	7	32
T. forsythia (%)	0.1	−	32	8	0.80	0.80	15.5	5.2 to 46.4
		+	8	31
P. gingivalis (%)	0.1	−	31	8	0.80	0.78	13.3	4.6 to 39.1
		+	9	31
P. intermedia (%)	0.4	−	29	11	0.72	0.73	6.7	2.5 to 18
		+	11	28
C. rectus (%)	0.1	−	25	15	0.62	0.63	2.7	1.1 to 6.6
		+	15	24
F. nucleatum (%)	2.8	−	24	16	0.59	0.60	2.2	0.9 to 5.3
		+	16	23
E. corrodens (%)	0.0	−	35	31	0.21	0.88	1.8	0.5 to 6.1
		+	5	8

− = no; + = yes.