Table 5.
Positive and Negative Predictive Values of Specific Thresholds of Selected Salivary Biomarkers and Plaque Biofilm Pathogens
| Biomarker | Threshold | Above Threshold | Periodontitis
|
PPV | NPV | |
|---|---|---|---|---|---|---|
| No (n) | Yes (n) | |||||
|
| ||||||
| MMP-8 (ng/ml) | 87.0 | − | 28 | 12 | 0.69 | 0.70 |
| + | 12 | 27 | ||||
|
| ||||||
| MMP-9 (ng/ml) | 240.0 | − | 28 | 12 | 0.69 | 0.70 |
| + | 12 | 27 | ||||
|
| ||||||
| Calprotectin (ng/ml) | 3.6 | − | 25 | 15 | 0.62 | 0.63 |
| + | 15 | 24 | ||||
|
| ||||||
| IL-6 (pg/ml) | 22.4 | − | 24 | 16 | 0.59 | 0.60 |
| + | 16 | 23 | ||||
|
| ||||||
| IL-1β (pg/ml) | 235.8 | − | 22 | 18 | 0.54 | 0.55 |
| + | 18 | 21 | ||||
|
| ||||||
| IL-10 (pg/ml) | 520.9 | − | 22 | 18 | 0.54 | 0.55 |
| + | 18 | 21 | ||||
|
| ||||||
| OPG (pg/ml) | 2.0 | − | 17 | 22 | 0.43 | 0.44 |
| + | 23 | 17 | ||||
|
| ||||||
| ICTP (ng/ml) | 0.7 | − | 16 | 23 | 0.40 | 0.41 |
| + | 24 | 16 | ||||
|
| ||||||
| T. denticola (%) | 0.2 | − | 33 | 7 | 0.82 | 0.83 |
| + | 7 | 32 | ||||
|
| ||||||
| T. forsythia (%) | 0.1 | − | 32 | 8 | 0.80 | 0.80 |
| + | 8 | 31 | ||||
|
| ||||||
| P. gingivalis (%) | 0.1 | − | 31 | 8 | 0.78 | 0.80 |
| + | 9 | 31 | ||||
|
| ||||||
| P. intermedia (%) | 0.4 | − | 29 | 11 | 0.72 | 0.73 |
| + | 11 | 28 | ||||
|
| ||||||
| C. rectus (%) | 0.1 | − | 25 | 15 | 0.62 | 0.63 |
| + | 15 | 24 | ||||
|
| ||||||
| F. nucleatum (%) | 2.8 | − | 24 | 16 | 0.59 | 0.60 |
| + | 16 | 23 | ||||
|
| ||||||
| E. corrodens (%) | 0.0 | − | 35 | 31 | 0.62 | 0.53 |
| + | 5 | 8 | ||||
PPV = positive predictive value; NPV = negative predictive value; − = no; + = yes.