Table 2.
Summary of sex-specific autosomewide linkage analysis results for LOD scores exceeding the empirically derived significance linkage thresholds for opioid dependence in African- and European-Americans (AA and EA).
| Population | African American (AA) | European American (EA) | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Sex | Male | Female | Male | |||||
| Chromosome | 3 | 6 | 7 | 17 | 7 | 11 | 16 | 4 |
| Cytogenetic location | 3q27.3 | 6q25.1 | 7p21.3 | 17p12 | 7q36.3 | 11q22.3 | 16q12.1 | 4q12-4q13.1 |
| Peak location (cM)* | 201.1 | 152.9 | 16.8 | 36.1 | 181.3 | 104 | 60.9 | 71.7 |
| Peak LOD score** | 2.32 | 1.86 | 1.95 | 1.99 | 2.18 | 1.85 | 1.93 | 3.29 |
| Pointwise p -value | 0.0005 | 0.002 | 0.0014 | 0.0012 | 0.0008 | 0.002 | 0.0014 | 0.00005 |
| Empirical autosome-wide p -value | 0.3 | 0.62 | 0.54 | 0.52 | 0.36 | 0.58 | 0.53 | 0.042 |
| LOD score for the opposite sex at the same location as the peak’s*** | −0.41 | 0.12 | −0.08 | 0.02 | −0.63 | 0.28 | 0.02 | 0.01 |
| Difference of the male-female LOD scores | 2.73 | 1.74 | 2.03 | 1.97 | 2.81 | 1.57 | 1.91 | 3.28 |
| Empirical p-value of the male-female LOD score difference | - | - | - | - | - | - | - | 0.002 |
| Number of families | 384 | 384 | 384 | 384 | 350 | 350 | 350 | 350 |
| Number of Merlin informative families | 30 | 30 | 30 | 30 | 44 | 44 | 44 | 83 |
| Suggestive Threshold | 1.78 | 1.78 | 1.78 | 1.78 | 1.77 | 1.77 | 1.77 | 1.73 |
| Significant Threshold | 3.16 | 3.16 | 3.16 | 3.16 | 3.16 | 3.16 | 3.16 | 3.11 |
Note:
*
cM, centiMorgan;
**
LOD, the logarithm of odd score;
***
for example, in the EA male column, the peak LOD score is 3.29 at 71.7 cM; then the LOD score for female at 71.7 cM is 0.01 (These numbers are in bold).