Table 1.
MicroCT-measured geometric or structural parameters for the proximal metaphyseal cortical and cancellous bone of the LC and GorabPrx1 tibiae, located just below the growth plate extending 10% of the tibial length distally.
| Parameters | LC | GorabPrx1 | Difference (%) |
|---|---|---|---|
| Metaphyseal cortical bone | |||
| Ct.Ar (mm2) | 0.890 ± 0.090 | 0.358 ± 0.078 b | −60 |
| Tt.Ar (mm2) | 1.413 ± 0.120 | 1.020 ± 0.180 b | −28 |
| Ma.Ar (mm2) | 0.523 ± 0.090 | 0.659 ± 0.150 | 26 |
| Ct.Th (mm) | 0.111 ± 0.015 | 0.053 ± 0.008 b | −52 |
| Imax (mm4) | 0.375 ± 0.072 | 0.209 ± 0.035 b | −44 |
| Imin (mm4) | 0.256 ± 0.046 | 0.076 ± 0.028 b | −70 |
| Ct.TMD (mgHA/ccm) | 1075 ± 20 | 1052 ± 17 a | −2 |
| Metaphyseal cancellous bone | |||
| BV/TV (%) | 9.6 ± 3.0 | 4.7 ± 1.7 b | −50 |
| Tb.Th (μm) | 46 ± 4 | 45 ± 5 | −3 |
| Tb.N (1/mm) | 4.2 ± 0.5 | 3.6 ± 0.5 a | −14 |
| Tb.Sp (μm) | 244 ± 29 | 281 ± 44 | 15 |
| Tb.TMD (mgHA/ccm) | 791 ± 31 | 870 ± 32 b | 10 |
Data are presented as mean ± SD.
Differences are calculated as (GorabPrx1-LC)/LC×100.
a
p<0.05 relative to LC.
b
p<0.001 relative to LC.