Table 3.
Whole-bone mechanical properties of 12 week-old LC and GorabPrx1 tibiae, measured by three-point bending testing.
Parameters | Unadjusted | Body weight-adjusted | ||||
---|---|---|---|---|---|---|
| ||||||
LC | GorabPrx1 | Diff (%) | LC | GorabPrx1 | Diff (%) | |
Max load (N) | 13.00 ± 1.77 | 6.97 ± 2.71a | −46 | 14.44 ±1.57 | 8.73 ±1.97a | −40 |
Stiffness (N/mm) | 148.1 ± 21.5 | 67.2 ± 32.1a | −55 | 153.1 ± 21.3 | 85.0 ± 26.0a | −45 |
Work-to-fracture (Nmm) | 12.50 ± 3.82 | 4.93 ± 4.41a | −61 | 18.22 ± 2.02 | 7.24 ± 3.68a | −60 |
Post-yield displacement (mm) | 0.48 ± 0.22 | 0.25 ± 0.23a | −47 | 0.71 ± 0.18 | 0.33 ± 0.21a | −54 |
Data are presented as mean ± SD.
Differences are calculated as (GorabPrx1-LC)/LC×100.
p<0.05 relative to LC.