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. Author manuscript; available in PMC: 2017 Nov 20.
Published in final edited form as: Periodontol 2000. 2009;50:52–64. doi: 10.1111/j.1600-0757.2008.00288.x

Table 1.

Major salivary gland secretion mediators associated with periodontal diseases

Marker Relationship with periodontal disease Type of periodontal disease
Specific
  Immunoglobulins (IgA, IgM, IgG) Interfere in adherence and bacterial metabolism / increased concentration in saliva of periodontal patients Chronic and aggressive
Nonspecific
  Mucins Interfere with the colonization of Aggregatibacter actinomycetemcomitans Aggressive
  Lysozyme Regulates biofilm accumulation Chronic
  Lactoferrin Inhibits microbial growth / increased correlation with A. actinomycetemcomitans Aggressive
  Histatin Neutralizes lipopolysaccharide and enzymes known to affect the periodontium Chronic and aggressive
  Peroxidase Interferes with biofilm accumulation / increased correlation with periodontal patients Chronic
Systemic
  C-reactive protein Increased concentration found in serum and saliva of periodontal patients Chronic and aggressive