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. 2017 Nov 16;11:3273–3280. doi: 10.2147/DDDT.S149411

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© 2017 Paškevičiūtė and Petrikaitė. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of statins on cancer cell apoptosis and necrosis.

Notes: (A) PANC-1 cells after double staining with Hoechst 33342 and propidium iodide: 1 – viable cells, 2 – apoptotic cells, and 3 – necrotic cells (magnification is 100×). (B) The percentage of apoptotic and necrotic cells in BxPC-3 cell line. (C) The percentage of apoptotic and necrotic cells in PANC-1 cell line. The asterisks (*) indicate p<0.05.

Abbreviations: EC₅₀, half maximal effective concentration; LOVA, lovastatin; MEVA, mevastatin; PITA, pitavastatin; SIMVA, simvastatin.