Table 5.

Comparison of cytokines before and after DC–CIK therapy

Parameter	CIK/DC–CIK	CIK/DC–CIK	Analysis method	Heterogeneity		OR	95% CI	P-value
	After treatment (n)	Before treatment (n)		I2 (%)	P-value
AgNOR	50	50	Random	67	0.08	1.05	0.40 to 1.70	0.002
IFN-γ	26	26	Random			33.91	30.68 to 37.14	<0.00001
IL-2	86	86	Random	97	<0.00001	19.56	9.74 to 29.39	<0.0001
IL-4	26	26	Random			−8.34	−10.06 to −6.62	<0.00001
IL-6	30	30	Random			−35.01	−59.02 to −11.00	0.004
IL-10	26	26	Random			−11.10	−13.13 to −9.07	<0.00001
IL-12	24	24	Random			12.25	1.53 to 22.97	0.03
TGF-β	56	56	Random	0	0.34	−0.35	−0.58 to −0.13	0.002

Abbreviations: AgNOR, silver-staining nucleolar organizer region; CI, confidence interval; CIK, cytokine-induced killer cells; DC–CIK, dendritic cells and CIK; OR, odds ratio.