Table 2.
Prevalence of comorbidity among patients with lower extremity amputations in 2010–2011 in Denmark
| Major amputations | Minor amputations | ||||
| Total, n (%) | Above knee, n (%) | Below knee, n (%) | Total, n (%) | p Value* | |
| n=1782 | n=1024 | n=758 | n=1101 | ||
| Peripheral vascular disorders | 1481 (83) | 873 (85) | 608 (80) | 625 (57) | <0.0001 |
| Atherosclerosis† | 1428 (80) | 844 (82) | 584 (77) | 589 (54) | <0.0001 |
| Hypertension‡ | 902 (51) | 577 (56) | 441 (58) | 599 (54) | 0.18 |
| Diabetes‡ | 697 (39) | 331 (32) | 366 (48) | 710 (64) | <0.0001 |
| Diabetic foot ulcer§ | 505 (18) | 224 (22) | 281 (37) | 522(47) | <0.0001 |
| Neuropathy§ | 174 (6) | 69 (7) | 105 (14) | 230 (21) | <0.0001 |
| Retinopathy§ | 112 (6) | 37 (4) | 75 (10) | 141 (13) | <0.0001 |
| Nephropathy§ | 85 (5) | 22 (2) | 63 (8) | 82 (7) | 0.0028 |
| Cardiac ischaemia§ | 597 (34) | 348 (34) | 249 (33) | 329 (30) | 0.04 |
| Cardiac arrhythmia | 536 (30) | 319 (31) | 215 (28) | 232 (21) | <0.0001 |
| Cerebrovascular disease¶ | 540 (30) | 317 (31) | 223 (29) | 195 (18) | <0.0001 |
| Congestive heart failure | 401 (23) | 228 (22) | 173 (23) | 191 (17) | 0.0009 |
| Stroke§ | 401 (23) | 234 (23) | 167 (22) | 144 (13) | <0.0001 |
| Arthrosis§ | 320 (18) | 202 (20) | 118 (16) | 195 (18) | 0.86 |
| Chronic pulmonary diseases | 356 (20) | 227 (22) | 129 (17) | 129 (12) | <0.0001 |
| Fluid and electrolyte disorders | 330 (19) | 211 (21) | 119 (16) | 123 (11) | <0.0001 |
| Emboli§ | 359 (20) | 231 (23) | 128 (17) | 88 (8) | <0.0001 |
| Renal failure | 252 (14) | 129 (13) | 123 (16) | 133 (12) | 0.11 |
| Tumour without metastasis | 243 (14) | 143 (14) | 100 (13) | 107 (10) | 0.0018 |
| Alcohol addiction | 227 (13) | 121 (12) | 106 (14) | 122 (11) | 0.18 |
| Obesity | 130 (7) | 60 (6) | 70 (9) | 127 (12) | 0.0001 |
| Rheumatoid arthritis | 139 (8) | 77 (8) | 62 (8) | 90 (8) | 0.71 |
| Depression | 124 (7) | 77 (8) | 47 (6) | 58 (5) | 0.069 |
| Dementia¶ | 110 (6) | 69 (7) | 43 (6) | 37 (3) | 0.0006 |
| Liver disease | 79 (4) | 40 (4) | 39 (5) | 51 (5) | 0.80 |
| Metastatic cancer | 50 (3) | 36 (3) | 14 (2) | 9 (1) | 0.0002 |
| Weight loss | 43 (2) | 30 (3) | 13 (2) | 12 (1) | 0.0155 |
| Bone cancer§ | 24 (1) | 14 (1) | 10 (1) | 2 (−) | 0.0013 |
*p<0.05, major vs minor amputation. Comorbidity, defined according to Elixhauser Comorbidity index.
†Includes only ICD-10- I170;
‡Includes uncomplicated and complicated conditions.
§Not included in the Elixhauser Comorbidity Index.
¶Included from the Charlson Comorbidity Index.