Table 3.

Comparison of MDPT versus JNC8 strategy

	People treated similarly* by both JNC8 and MDPT strategies	People treated more intensively by MDPT strategy	People treated more intensively by JNC8 strategy
% of population	12.4	47.8	39.8
Mean initial 10-year CVD risk	13.4	15.2	13.1
Mean post-10 years of treatment of 10-year CVD risk	14.1	14.7	14.7
Averted QALY loss from CVD events, per 1000 patients treated, compared with JNC8	1.39	3.01	1.54
Averted QALY loss from adverse events, per 1000 patients treated, compared with JNC8	−0.03	−0.09	−0.02
Total QALYs saved, per 1000 patients treated, compared with JNC8	40.0	74.9	44.6

*‘Treated similarly’ was defined as rounded mean treatment dose level over the patient’s lifetime being the same between the JNC8 and MDPT strategies.

CVD, cardiovascular disease; JNC8, Eighth Joint National Committee; MDPT, Markov decision process-based treatment; QALY, quality-adjusted life-year.