Table 3.
Associations of rest-activity circadian rhythm parameters and total hip areal bone mineral density (aBMD) in older men at MrOS Sleep Visit 1.
| Predictor | aBMD at Sleep Visit 1 (age and site adjusted) |
aBMD at Sleep Visit 1 (multivariate adjusted) |
||
|---|---|---|---|---|
| LS means (95% CI) | p-Trend | LS means (95% CI) | p-Trend | |
| Amplitude (counts/min) | ||||
| Q1 (ref): 278.83 to < 2893.84 | 0.96 (0.95, 0.97) | 0.457 | 0.95 (0.94, 0.96) | 0.116 |
| Q2: 2893.84 to < 3536.64 | 0.96 (0.95, 0.97) | 0.96 (0.95, 0.97) | ||
| Q3: 3536.64 to < 4190.04 | 0.96 (0.94, 0.97) | 0.96 (0.95, 0.97) | ||
| Q4: 4190.04 to 12,357.70 | 0.95 (0.94, 0.97) | 0.96 (0.95, 0.97) | ||
| Mesor (counts/min) | ||||
| Q1 (ref): 567.86 to < 1847.12 | 0.96 (0.95, 0.97) | 0.620 | 0.95 (0.94, 0.97) | 0.486 |
| Q2: 1847.12 to < 2134.04 | 0.96 (0.95, 0.97) | 0.96 (0.95, 0.97) | ||
| Q3: 2134.04 to < 2424.78 | 0.95 (0.94, 0.96) | 0.95 (0.94, 0.96) | ||
| Q4: 424.78 to 7592.08 | 0.96 (0.95, 0.97) | 0.96 (0.95, 0.97) | ||
| Pseudo F-statistic (no unit) | ||||
| Q1 (ref): 8.27 to < 689.559 | 0.96 (0.95, 0.98) | 0.009 | 0.95 (0.94, 0.97) | 0.784 |
| Q2: 689.56 to < 959.56 | 0.96 (0.95, 0.98) | 0.96 (0.95, 0.97) | ||
| Q3: 959.56 to < 1311.94 | 0.95 (0.94, 0.97) | 0.96 (0.95, 0.97) | ||
| Q4: 1311.94 to 4501.43 | 0.94 (0.93, 0.96) | 0.95 (0.94, 0.96) | ||
| Alpha statistic (no unit) | ||||
| Q1 (ref): − 0.82 to <− 0.47 | 0.96 (0.95, 0.97) | 0.223 | 0.96 (0.95, 0.97) | 0.610 |
| Q2: − 0.47 to <− 0.35 | 0.95 (0.94, 0.96) | 0.95 (0.94, 0.96) | ||
| Q3: − 0.35 to <− 0.18 | 0.95 (0.94, 0.96) | 0.95 (0.94, 0.96) | ||
| Q4: − 0.18 to 1.00 | 0.97 (0.96, 0.98) | 0.96 (0.95, 0.97) | ||
| Beta statistic (no unit) | ||||
| Q1 (ref): 0.71 to < 4.94 | 0.96 (0.95, 0.97) | 0.229 | 0.95 (0.94, 0.96) | 0.463 |
| Q2: 4.94 to < 8.82 | 0.96 (0.95, 0.97) | 0.97 (0.96, 0.98) | ||
| Q3: 8.82 to < 20.85 | 0.95 (0.94, 0.96) | 0.95 (0.94, 0.97) | ||
| Q4: 20.85 to 746.20 | 0.95 (0.94, 0.96) | 0.95 (0.94, 0.96) | ||
| Acrophase (hours, min) | ||||
| − 1.5 SD | 0.94 (0.92, 0.97) | 0.618 | 0.94 (0.92, 0.97) | 0.898 |
| Mean (ref) | 0.96 (0.95, 0.96) | 0.96 (0.95, 0.96) | ||
| + 1.5 SD | 0.93 (0.91, 0.96) | 0.94 (0.92, 0.97) | ||
Bold values indicate significance at p < 0.05.
Multivariate model adjustments: amplitude, pseudo F-statistic, mesor multivariate models adjusted for: BMI, heart attack, diabetes, alcohol, caffeine, PASE, depression, melatonin, beta blocker use, 25(OH) vitamin D, urinary calcium. Alpha and beta multivariate models adjusted for: BMI, smoking, alcohol, depression. Acrophase multivariate model adjusted for: race, BMI, melatonin, alcohol, smoking, caffeine, PASE, depression.