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. Author manuscript; available in PMC: 2017 Nov 20.
Published in final edited form as: Crit Rev Immunol. 2016;36(6):485–510. doi: 10.1615/CritRevImmunol.2017020284

FIGURE 1. Transcriptional pathways by which Ets1 regulates B cell differentiation to plasma cells.

FIGURE 1

Ets1 functions to stimulate and/or maintain the expression of the transcription factor Pax5, which is crucial for regulating B cell identity genes. Pax5 and Ets1 may also cooperate to regulate B cell genes. Ets1 also represses both the expression and the function of the transcription factor Blimp1, which is necessary to promote the plasma cell fate. Ets1 may also promote the expression of additional target genes that regulate other aspects of B cell function, like formation of germinal centers, isotype-switching and memory B cell formation.