. Author manuscript; available in PMC: 2017 Nov 20.

Published in final edited form as: Arch Pathol Lab Med. 2015 Jul 1;139(11):1362–1372. doi: 10.5858/arpa.2014-0624-OA

Table 3.

Functions and Interactions for 18 miRNAs with high Expression Variation in HPV− Tumors from Non-smoking Patients.

miRNA	Cellular Function/Interactions
HS_240	implicated in oesophageal carcinoma
hsa-miR-122a	liver specific miRNA
hsa-miR-154^*	ZNFs are inferred targets
hsa-miR-302a	G1/S phase transition
hsa-miR-302a^*	non-functional
hsa-miR-302b	epithelial-mesenchymal transition⁵⁷
hsa-miR-302d	G1/S phase transition
hsa-miR-376b	expressed by endothelial cells exposed to hypoxia⁵⁸
hsa-miR-431	binds CD81 (signal transduction)
hsa-miR-506	binds CDK6 (phosphorylates Rb)
hsa-miR-507	colony formation, invasion, growth, and apoptosis (inferred)
hsa-miR-508	MBD1, p53, and Myc are inferred targets
hsa-miR-509	Binds NTRK3 (neuronal differentiation and survival)
hsa-miR-510	binds SPDEF (SAM Pointed Domain Containing ETS Transcription Factor)
hsa-miR-513	association with skin cancer (inferred)
hsa-miR-514	association with skin cancer (inferred)
hsa-miR-539	colony formation, invasion, growth, and apoptosis (inferred)
hsa-miR-551b	DNMT3A, TRAF1, and E2F6 are inferred targets

less prominent form of the miRNA

CD81= Cluster of Differentiation 81

CDK6= Cyclin-Dependent Kinase 6

DNMT3A= DNA (cytosine-5)-Methyltransferase 3A

E2F6= Transcription Factor E2F6

ETS= E26 Transformation-Specific

HPV= Human Papillomavirus

MBD1= Methyl-CpG-Binding Domain Protein 1

miRNA= microRNA

NTRK3= Neurotrophic Tyrosine Kinase, receptor, type 3

p53= tumor protein 53

SAM= Serine Alpha Motif

TRAF1= TNF (Tumor Necrosis Factor) Receptor-Associated Factor 1

ZNF= Zinc Finger proteins