Table 2.
Standardized hazard ratio estimates for 10-year all-cause mortality for 7,944 CNICS patients, by selected viral load threshold values of k, combined from 100 imputations.
| Standardizeda hazard ratio (95%
confidence interval) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
k, cpm |
No.b of deaths |
No.b of Patients |
<20 cpmc |
No.b of deaths |
No.b of patients |
20 to
<k cpm |
No.b of deaths |
No.b of patients |
k to 999 cpm |
No. of deaths |
No. of patients |
>999 cpm |
|
|
|
|
|
|
||||||||
| 20 | 310 | 4545 | 1 | — | — | — | 230 | 2184 | 1.18 (0.93, 1.50) | 322 | 1215 | 1.96 (1.56, 2.46)d |
| 30 | 54 | 535 | 1.17 (0.75, 1.84) | 176 | 1649 | 1.17 (0.91, 1.50) | ||||||
| 40 | 75 | 708 | 1.19 (0.81, 1.73) | 155 | 1476 | 1.18 (0.91, 1.52) | ||||||
| 50 | 96 | 934 | 1.17 (0.83, 1.66) | 134 | 1215 | 1.18 (0.92, 1.53) | ||||||
| 75 | 121 | 1273 | 1.10 (0.79, 1.47) | 109 | 911 | 1.29 (0.98, 1.70) | ||||||
| 100 | 142 | 1454 | 1.12 (0.85, 1.50) | 88 | 730 | 1.25 (0.93, 1.68) | ||||||
| 130 | 152 | 1592 | 1.09 (0.83, 1.44) | 78 | 592 | 1.39 (1.02, 1.88) | ||||||
| 200 | 174 | 1776 | 1.11 (0.85, 1.44) | 56 | 409 | 1.44 (1.00, 2.07) | ||||||
| 300 | 189 | 1912 | 1.11 (0.86, 1.43) | 41 | 272 | 1.58 (1.07, 2.35) | ||||||
| 400 | 197 | 1991 | 1.12 (0.87, 1.45) | 33 | 193 | 1.74 (1.10, 2.74) | ||||||
| 500 | 201 | 2041 | 1.11 (0.86, 1.43) | 29 | 143 | 1.77 (1.05, 2.99) | ||||||
Abbreviation: cpm, copies/mL.
Standardized estimates controlled for age, sex, race/ethnicity, male-to-male sexual contact, injection drug use, smoking, at-risk alcohol use, pre-ART viral load, year of ART initiation, ART regimen, CD4 count, clinical AIDS status, status of other clinical conditions (chronic hepatitis B, chronic hepatitis C, past diagnosis of any cancer excluding nonmelanoma skin cancer), statin use, and study site.
Averaged over 100 imputations, rounded to nearest integer.
Viral load <20 copies/mL was reference category across k.
Hazard ratio for viral loads >999 copies/mL was unchanged across k.