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. 2017 Oct 23;13(10):e1007048. doi: 10.1371/journal.pgen.1007048

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© 2017 Salehi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Cochlear whole mounts of WT, Nrp1^fl/fl;Pax2^Cre mice at P5 (n = 4 per group) and 4 months (n = 5 per group) were immunostained with presynaptic marker CtBP2. Panel A and B shows CtBP2 immunostaining of the 4-month-old mice (A, B). The number of CtBP2 puncta was compared separately to the number of inner and outer hair cells per section. CtBP2 ratios of IHCs did not differ significantly between WT and Nrp1^fl/fl;Pax2^Cre mutants from P5 to maturity (C). OHC synaptic ribbon ratios of 4-month-old Nrp1^fl/fl;Pax2^Cre demonstrated a significant decrease in CtBP2 counts in the basal turn (p<0.05). CtBP2 counts of the IHCs showed two cochlea out of five with nearly 50% decreased numbers of the puncta when compared to WT controls; however, the average of the counts (five cochlea) did not show a statistically significant difference (D). *p<0.05. Scale bar = 10 μm.