Table 2.
Treatment received in the intention-to-treat samples.
| Therapy | Total sample (N=164) | Per-protocol sample (n=117) | ||||
| Smartphone CBT + medication change (n=81) | Medication change alone (n=83) | Smartphone CBT + medication change (n=60) | Medication change alone (n=57) | |||
| Pharmacotherapy | ||||||
| Discontinuation of protocol antidepressant treatment by escitalopram or sertraline by week 9, n (%) | 16 (20) | 14 (17) | 10 (17) | 8 (14) | ||
| Discontinuation reason, n | ||||||
| Prescription of prohibited drugs | 6 | 9 | 4 | 5 | ||
| Amelioration | 1 | 1 | — | 1 | ||
| Deterioration | 1 | — | 1 | — | ||
| Side effects | 3 | 1 | 1 | — | ||
| Other | 5 | 3 | 4 | 2 | ||
| Discontinuation of any antidepressant therapy by week 9, n (%) | 5 (6) | 2 (2) | 2 (3) | 2 (4) | ||
| Escitalopram dosage at week 9 (mg/day), mean (SD) | 9.5 (3.0), n=48 | 10.0 (3.2), n=49 | 9.7 (3.1), n=38 | 10.1 (2.9), n=34 | ||
| Sertraline dosage at week 9 (mg/day), mean (SD) | 79.0 (26.7), n=25 | 83.6 (23.4), n=29 | 81.6 (26.1), n=19 | 83.0 (24.9), n=22 | ||
| Smartphone CBT | ||||||
| Sessions completed, n | — | — | ||||
| 0 | 1 | — | ||||
| 3 | 1 | 1 | ||||
| 4 | 4 | 3 | ||||
| 5 | 4 | 2 | ||||
| 6 | 11 | 8 | ||||
| 7 | 17 | 13 | ||||
| 8 | 43 | 33 | ||||
| Time per session (days), mean (SD) | 10.8 (4.2) | — | 10.7 (4.0) | — | ||
| Number of mind maps for self-monitoring, mean (SD) | 11.2 (11.4) | — | 10.8 (10.3) | — | ||
| Number of behavioral activation tasks, mean (SD) | 14.4 (17.1) | — | 14.6 (17.8) | — | ||
| Number of alternative thoughts, mean (SD) | 6.1 (6.0) | — | 6.5 (6.0) | — | ||