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Summary of TRPM8 mutant responses to chemical agonists and CFA, compared with human TRPM8-WT or mouse-WT
| Mutant | Icilin | Menthol | CFA | Description/function |
|---|---|---|---|---|
| hΔ801 | ↓ | ↓ | = | Lung epithelial variant |
| hY745D | ↓ | ↓ | = | Menthol/icilin binding site |
| hR1008Q | N.T. | ↓ | ↓ | PIP2 binding, cold sensitivity |
| hL1009R | N.T. | ↓ | ↓ | PIP2 binding, cold sensitivity |
| mS921G | N.T. | = | ↑ | Mouse to human substitution |
| mS927S | N.T. | = | ↑ | Mouse to human substitution |
| mS932S | N.T. | = | = | Mouse to human substitution |
N.T., not tested; WT, wild type.
