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. Author manuscript; available in PMC: 2018 Oct 6.
Published in final edited form as: Annu Rev Cell Dev Biol. 2017 Aug 11;33:291–318. doi: 10.1146/annurev-cellbio-100616-060447

Figure 10. Hypothetical asymmetric nucleosome density in leading vs. lagging strand.

Figure 10

As PCNA has been shown to play a central role in recruiting new histones for deposition on newly synthesized DNA, the increased density of PCNA on the lagging strand could serve to increase histone density on the lagging strand when compared to the leading strand. Increased histone density would chance the chromatin state of these regions, possibly as a way to bias the transcriptional output of the two sister chromatids.