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. Author manuscript; available in PMC: 2018 Oct 6.
Published in final edited form as: Annu Rev Cell Dev Biol. 2017 Aug 11;33:291–318. doi: 10.1146/annurev-cellbio-100616-060447

Figure 4. Asymmetries in DNA replication effect chromatin maturation following fork passage.

Figure 4

(A) The replisome approaches the bound transcription factor with Pol II transcribing in the same direction as the fork. The approaching helicase causes the transcription factor to dissociate. Due to the fact that the lagging strand is still being processed, the transcription factor will preferentially bind the leading strand. (B) Once bound, the transcription factor can initiate transcription, which helps structure and order the nucleosomes on the leading strand. (C) The leading strand now has ordered, phased nucleosomes whereas the lagging strand, due to lack of transcription, still has disordered nucleosomes.