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. Author manuscript; available in PMC: 2017 Nov 20.
Published in final edited form as: Compr Physiol. 2015 Dec 15;6(1):507–526. doi: 10.1002/cphy.c150022

Figure 3.

Figure 3

Mitophagy: Summary of steps involved in mitophagy. The depolarized mitochondrion leads to accumulation of PINK1, which phosphorylates Mfn2, which acts as a lure for Parkin. Parkin binding Mfn2 triggers mitophagy. Outer membrane proteins, including both Mfn’s and VDAC, are ubiquitinated. P62 is recruited, binding the ubiquitinated proteins, linking them to LC3. The isolation membrane elongtes and eventually engulfs the mitochondrial pieces destined for autophagy, forming the autophagosome, which eventually fuses with the lysosome, leading to degradation of the enclosed mitochondria.