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. 2017 Nov 20;12(11):e0188006. doi: 10.1371/journal.pone.0188006

Fig 1. FXYD1 is implicated in urinary concentration.

Fig 1

Box and whisker plot of the osmolality of daytime (afternoon) samples of male mouse WT and knockout (KO) urine at baseline and after water deprivation, showing a difference in baseline osmolality but the near-normal ability of the KO to concentrate its urine. The asterisks indicate a P value of <0.0001, 2-tailed Student’s t-test. When calculated as average ± SEM the results were as follows. WT control conditions, 2,019 ± 143, n = 20; KO control conditions 1,161 ± 123, n = 21; Student’s t-test, P < 0.0001. WT after 36 hours water deprivation, 4,224 ± 140, n = 8; KO water deprivation, 3,716 ± 383, n = 8; t-test, P = 0.26. Female mice were also tested in control conditions, and the results for baseline osmolality were WT, 2,169+/-92, n = 7; KO, 1,085+/-108, n = 7, t-test P < 0.001.