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. 2017 Nov 20;12(11):e0187227. doi: 10.1371/journal.pone.0187227

Table 5. Total ambulatory care costs per year from 1 to 7 years before TKR by treatment group.

Total ambulatory care costs (€) HA group who had TKR N-HA group who had TKR P-values*
year TKR-1 n 1,296 366  
  Mean (±SD) 744 (±600) 805 (±652) 0.104
  Median [Q1—Q3] 597 [371–934] 618 [402–1,8]  
year TKR-2 n 997 184  
  Mean (±SD) 661 (±484) 686 (±625) 0.544
  Median [Q1—Q3] 526 [336–808] 492 [324–812]  
year TKR-3 n 621 97  
  Mean (±SD) 615 (±448) 613 (±497) 0.612
  Median [Q1—Q3] 485 [307–758] 473 [279–759]  
year TKR-4 n 387 55  
  Mean (±SD) 592 (±437) 508 (±373) 0.088
  Median [Q1—Q3] 474 [309–735] 395 [252–665]  
year TKR-5 n 228 31  
  Mean (±SD) 571 (±420) 435 (±309) 0.039
  Median [Q1—Q3] 472 [285–720] 331 [233–553]  
year TKR-6 n 117 16  
  Mean (±SD) 528 (±324) 485 (±352) 0.384
  Median [Q1—Q3] 463 [294–674] 315 [265–687]  
year TKR-7 n 47 10  
  Mean (±SD) 474 (±281) 544 (±394) 0.983
  Median [Q1—Q3] 396 [296–584] 358 [278–859]  

No missing data

n: number of patients, TKR: total knee replacement, HA group: patients who received at least one IA HA injection during their follow-up period, N-HA group: patients who received only CS as IA injections, IA: intra-articular, HA: hyaluronic acid, CS: corticosteroids.

* T-test, Wilcoxon (for mean difference)