Fig 2. Reduced order complement model training.

An ensemble of model parameters was estimated using multiobjective optimization from dynamic C3a and C5a measurements with and without zymosan. The model was trained using C3a and C5a measurements in the absence of zymosan (A–B) or in the presence of 1 mg/ml zymosan (C–D). The solid black lines show the simulated mean value of C3a or C5a for the ensemble, while the dark shaded region denotes the 99% confidence interval of mean. The light shaded region denotes the 99% confidence interval of the simulated C3a and C5a concentration. The experimental training data (points) was taken from Morad et al [35]. All initial conditions not specified by the experimental condition were assumed to be at zero or their physiological serum levels unless otherwise noted (S1 Table).