Serum T4 levels after exposure for 2 or 4 months in NOD.H2h4 mice to rodent diets containing Lo, Con, or Hi Se (0.0, 0.1, or 1.0 mg/kg Se, respectively) together with iodide-supplemented water. Nontransgenic NOD.H2h4 males and females after (A) 2 months and (B) 4 months. Transgenic TSHR/NOD.H2h4 males and females after (C) 2 months and (D) 4 months. Data are shown as the mean + standard error of the mean values for T4 (mg/dL); the number of mice in each group is given in parentheses. Statistically significant differences: (B) males *P < 0.05 (ANOVA).