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Pten+/− mice develop pheochromocytomas of the adrenal medulla. Morphology of the wild-type adrenal (A) and the Pten+/− adrenal containing a pheochromocytoma (B). (Magnification, ×40.) The normal medulla can be seen in the center of the wild-type adrenal cortex. Paraffin sections were stained with hematoxylin/eosin. PTEN+/− animals (mutant) have elevated levels of serum norepinephrine (C) and epinephrine (D) relative to wild type.
