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Fibrosis evidenced in hepatic organoids (3d HepaRG/HSC). a) Viability determination of organoids after 24 h exposure of chemical x after 1, 2, 4 and 7 exposures. b) D) mRNA levels of HSC activation marker COL1A1 in hepatic organoids after 1,2,4 and 7 exposures of 180 and 540 μM PBO.
