Fig. 5.

Illustration of predicted liver and blood concentrations of chemical X alongside in vitro assay results overlap. Differences in dose response are seen between the different test systems, e.g. Cyp3A4 an approx. 100 fold difference in concentration between cell free and the metabolically active HepaRG cells. This needs to be taken into account when translating the data for in vivo relevance. These data could be considered as possible points of departure for chemical x. Reprinted from OECD [69].)