Table 2.

Odds ratios (with 95% confidence intervals) representing association between aspects of cannabis use and suicidal thoughts and behaviours in full sample of 13,986 male and female twins from the Australian Twin Registry.

	Cannabis ever use
	Unadjusted OR	Adjusted OR
Major Depressive Disorder	1·15 (1·06, 1·25)	1·02 (0·93, 1·12)
Suicidal ideation	1·26 (1·16, 1·37)	1·08 (0·98, 1·19)
Suicidal ideation >1 day	1·35 (1·19, 1·54)	1·19 (1·02, 1·38)
Suicide plan	1·34 (1·15, 1·56)	1·11 (0·93, 1·33)
Suicide attempt	1·76 (1·43, 2·16)	1·13 (0·88, 1·44)
	Early Cannabis Use
	In the full sample		In the subsample of ever users (N = 7361)
	Unadjusted OR	Adjusted OR	Unadjusted OR	Adjusted OR
Major Depressive Disorder	1·52 (1·36, 1·69)	1·28 (1·13, 1·45)	1·50 (1·33, 1·70)	1·33 (1·16, 1·53)
Suicidal ideation	2·03 (1·82, 2·26)	1·57 (1·38, 1·78)	2·03 (1·79, 2·29)	1·68 (1·46, 1·92)
Suicidal ideation >1 day	2·08 (1·78, 2·43)	1·55 (1·29, 1·87)	2·01 (1·68, 2·40)	1·63 (1·33, 2·00)
Suicide plan	2·39 (2·01, 2·84)	1·77 (1·44, 2·18)	2·44 (2·00, 2·99)	2·04 (1·62, 2·57)
Suicide attempt	3·63 (2·94, 4·47)	2·04 (1·58, 2·64)	3·52 (2·74, 4·51)	2·38 (1·78, 3·17)
	Frequent Cannabis Use (≥ 100 times)
	In the full sample		In the subsample of ever users (N = 7361)
	Unadjusted OR	Adjusted OR	Unadjusted OR	Adjusted OR
Major Depressive Disorder	1·74 (1·55, 1·95)	1·53 (1·35, 1·73)	1·74 (1·54, 1·97)	1·60 (1·40, 1·83)
Suicidal ideation	2·47 (2·20, 2·76)	1·96 (1·73, 2·23)	2·52 (2·22, 2·86)	2·07 (1·81, 2·38)
Suicidal ideation >1 day	2·27 (1·93, 2·66)	1·69 (1·40, 2·03)	2·19 (1·82, 2·62)	1·68 (1·38, 2·05)
Suicide plan	2·55 (2·13, 3·05)	1·81 (1·47, 2·22)	2·57 (2·10, 3·16)	1·94 (1·55, 2·42)
Suicide attempt	3·46 (2·78, 4·30)	1·95 (1·51, 2·51)	3·19 (2·49, 4·10)	2·12 (1·61, 2·80)

Adjusted for sex, age, cohort, alcohol use ≤16 (cohort 1) or ≤14 (cohorts 2, 3), nicotine use ≤16 (cohort 1) or ≤12 (cohorts 2, 3), MZ, opposite sex DZ, conduct, depressed mood or anhedonia ≤15 (not for MDD), childhood sexual abuse