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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Hepatology. 2017 Oct 30;66(6):1952–1967. doi: 10.1002/hep.29374

Fig. 6.

Fig. 6

cMet and Cdk6 mediated the inhibitory effect of miR-206 on the development of HCC in both AKT/Ras and cMyc mice. (A) Macroscopic (upper panel) and microscopic (lower panel) appearance of livers from AKT/Ras (n=10), AKT/Ras/miR-206 (n=10), AKT/Ras/miR-206/Ccnd1 (n=10), AKT/Ras/miR-206/Cdk6 (n=10) and AKT/Ras/miR-206/cMet mice (n=10) stained with H&E (100×). (B) Kaplan Meier survival curves of AKT/Ras, AKT/Ras/miR-206, AKT/Ras/miR-206/Ccnd1, AKT/Ras/miR-206/Cdk6 and AKT/Ras/miR-206/cMet mice. (C) Average liver weight of AKT/Ras, AKT/Ras/miR-206, AKT/Ras/miR-206/Ccnd1, AKT/Ras/miR-206/Cdk6 and AKT/Ras/miR-206/cMet mice. (D) Macroscopic (upper panel) and microscopic (lower panel) appearance of livers from cMyc (n=10), cMyc/miR-206 (n=10), cMyc/miR-206/Ccnd1 (n=10), cMyc/miR-206/Cdk6 (n=10) and cMyc/miR-206/cMet mice (n=10) stained with H&E (100×). (E) Kaplan Meier survival curves of cMyc, cMyc/miR-206, cMyc/miR-206/Ccnd1, cMyc/miR-206/Cdk6 and cMyc/miR-206/cMet mice. (F) Average liver weight of cMyc, cMyc/miR-206, cMyc/miR-206/Ccnd1, cMyc/miR-206/Cdk6 and cMyc/miR-206/cMet mice. Data represent mean ± SEM. NS: no significance; **p < 0.01 and ***p < 0.001.